This submission contains the mass spectrometry files for the manuscript by Garg et al. that describes the identification and functional characterization of the tetrahymena mediator complex. AP-MS experiments were performed from tetrahymena thermophila cells and MS files were acquired on 5600 TripleTOF and LTQ mass spectrometers. Please refer to the individual Tables 1 for additional details of submitted files. For questions, please contact Jean-Philippe Lambert (Jean-Philippe.Lambert@crchudequebec.ulaval.ca).