Set1 is the catalytic subunit of an evolutionarily conserved complex, SET1C or COMPASS, which methylates histone H3 at lysine 4 and serves as a scaffold for the association of seven tightly bound polypeptides: Swd1, Swd2, Swd3, Bre2, Sdc1, Spp1, and Shg1. Our results reveal that Set1 interacts with several importins as well as RGG motif-containing proteins, providing new insights into the mechanisms by which Set1 moves between cytoplasmic and nuclear compartments. We uncover that SET1C likely cooperates with other chromatin regulators, particularly via the Snf2 component of the SWI/SNF complex. Here, we study the Snf2 post-translational modifications (PTM) in either WT or set1∆ strains.