PXD001061

PXD001061 is an original dataset announced via ProteomeXchange.

Title	Uncovering Global SUMOylation Signaling Networks in a Site-Specific Manner
Description	SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution mass spectrometry, we have studied global SUMOylation in mammalian cells and in a site-specific manner, identifying a total of over 4,300 SUMOylation sites in over 1,600 proteins. Moreover, for the first time in excess of 1,000 SUMOylation sites were identified under standard growth conditions. SUMOylation dynamics were quantitatively studied in response to SUMO protease inhibition, proteasome inhibition and heat shock.
HostingRepository	PRIDE
AnnounceDate	2014-09-04
AnnouncementXML	Submission_2014-09-15_01:21:56.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ivo Hendriks
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	sumoylated lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2014-06-13 08:53:00	ID requested
1	2014-09-04 03:47:43	announced
⏵ 2	2014-09-15 01:21:57	announced	Updated publication reference for PubMed record(s): 25218447.

Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC, Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol, 21(10):927-36(2014) [pubmed]

curator keyword: Biological

submitter keyword: SUMO, SUMO2, SUMO-2, QQTGG, Q87R

Alfred C.O. Vertegaal
contact affiliation	Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands
contact email	a.c.o.vertegaal@lumc.nl
lab head
Ivo Hendriks
contact affiliation	Leiden University Medical Center
contact email	ivo.a.hendriks@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/09/PXD001061

PRIDE project URI

• PRIDE
  1. PXD001061
     1. Label: PRIDE project
     2. Name: Uncovering Global SUMOylation Signaling Networks in a Site-Specific Manner