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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2017-04-07
  • AnnouncementXML: Submission_2017-04-07_01:15:02.xml
  • DigitalObjectIdentifier: http://dx.doi.org/10.6019/PXD005620
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Supported dataset by repository
  • PrimarySubmitter: Fabia Fricke
  • Title: TGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
  • Description: DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopitz, J. (2015) Protein Sci. 24, 1686-94; Lee, J., Ballikaya, S., Schonig, K., Ball, C. R., Glimm, H., Kopitz, J. & Gebert, J. (2013) PloS one. 8, e57074]. Whether this receptor expression in MSI tumor cells also impacts the exosomal proteomic cargo of these cells is still unknown.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: Deamidated; Oxidation; Carbamidomethyl
  • Instrument: LTQ Orbitrap

Dataset History

VersionDatetimeStatusChangeLog Entry
02016-12-22 02:14:11ID requested
12017-04-07 01:15:03announced

Publication List

  1. Fricke F, Lee J, Michalak M, Warnken U, Hausser I, Suarez-Carmona M, Halama N, Schnölzer M, Kopitz J, Gebert J, TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Commun Signal, 15(1):14(2017) [pubmed]

Keyword List

  1. submitter keyword: Exosomes, Proteomics, Transforming Growth Factor Beta Receptor Type 2, DNA Mismatch Repair Deficiency, Microsatellite Instability, Colorectal Cancer, LC-MSMS

Contact List

    Prof. Juergen Kopitz
    • contact affiliation: PI, Dept. Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg
    • contact email: juergen.kopitz@med.uni-heidelberg.de
    • lab head:
    Fabia Fricke
    • contact affiliation: PhD Student
    • contact email: f.fricke@dkfz-heidelberg.de
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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