PXD005629

PXD005629 is an original dataset announced via ProteomeXchange.

Title	A proteomic analysis of human olfactory bulb
Description	Olfactory sensory neurons distinguish a large variety of odor molecules and direct the information through their axons to the olfactory bulb, the first site for the processing of olfactory information in the brain. Olfaction is very important for most mammals for the maintenance of a good quality of life. Accumulating evidences endorse that olfactory sensory decline is connected with neurodegenerative disorders including schizophrenia, depression, multiple sclerosis, Huntington's, Alzheimer's and Parkinson's diseases. For several decades, neuroanatomical, volumetric, and histological approaches have been the gold standard techniques employed to characterize the olfactory bulb functionality. Diagnosis and treatment of olfactory dysfunction remain significant health care challenges to society. Novel strategies and clues that assist in the identification of biomarker and drug development for aid in the prevention and cure of neurological diseases are necessary. However, little attention has been focused specifically on the molecular composition of the olfactory bulb from the perspective of proteomics. To this end, an in-depth mapping of the olfactory bulb proteome was carried out using high resolution tandem mass spectrometry, revealing a repertoire of 7,754 proteins. A large proportion of the identified proteins were predicted to be involved in diverse biological processes including signal transduction, metabolism, transport, olfaction and protein synthesis. Pathway analysis of the identified proteins shows that, these proteins are predominantly involved in metabolic and neural processes, chromatin modeling, and synaptic vesicle transport associated with neuronal transmission. In total, our study offers valuable understandings into the molecular composition of the human olfactory bulb proteome that could possibly help neuroscience community to understand the olfactory bulb better and open avenues for intervention strategies for olfactory dysfunction in the future.
HostingRepository	PRIDE
AnnounceDate	2017-08-23
AnnouncementXML	Submission_2017-08-23_00:04:44.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keshava Prasad T. S.
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	6340 Ion Trap LC/MS; LTQ; LTQ Orbitrap Velos; Q TRAP; Q-Tof ultima; 6220 Time-of-Flight LC/MS; MALDI Synapt MS; Synapt MS; maXis; 6520 Quadrupole Time-of-Flight LC/MS; LTQ FT; Orbitrap Fusion ETD; autoflex; ultraflex; LCQ Classic; TripleTOF 5600; QSTAR; Q Exactive; 6410 Triple Quadrupole LC/MS; 4700 Proteomics Analyzer; LTQ Orbitrap; 4800 Proteomics Analyzer; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-02 06:01:27	ID requested
⏵ 1	2017-08-23 00:04:45	announced

Dammalli M, Dey G, Madugundu AK, Kumar M, Rodrigues B, Gowda H, Siddaiah BG, Mahadevan A, Shankar SK, Prasad TSK, Proteomic Analysis of the Human Olfactory Bulb. OMICS, 21(8):440-453(2017) [pubmed]

curator keyword: Biological

submitter keyword: Tissue, protein biomarkers, bRPLC, LTQ-Orbitrap, neuroproteomics.

Dr. T. S. Keshava Prasad
contact affiliation	Faculty Scientist,Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
contact email	keshav@ibioinformatics.org
lab head
Keshava Prasad T. S.
contact affiliation	Institute of Bioinformatics, Bangalore, Karnataka, India.
contact email	keshav@ibioinformatics.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD005629

PRIDE project URI

• PRIDE
  1. PXD005629
     1. Label: PRIDE project
     2. Name: A proteomic analysis of human olfactory bulb