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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-02-18
  • AnnouncementXML: Submission_2019-04-01_00:27:32.xml
  • DigitalObjectIdentifier: http://dx.doi.org/10.6019/PXD011796
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Supported dataset by repository
  • PrimarySubmitter: Deborah Simpson
  • Title: Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV
  • Description: Neutrophil Extracellular Traps (NETs) are chromatin-derived extracellular structures that are expelled from neutrophils in response to infectious or inflammatory stimuli. NET DNA structures are decorated with proteins including histones, myeloperoxidase and neutrophil elastase. NETs are implicated in the development of auto-immunity in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalisation of intracellular neoepitopes e.g. dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy individuals, and from patients with RA and SLE.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: Oxidation; Carbamidomethyl
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-11-22 01:52:34ID requested
12019-02-18 06:53:07announced
22019-04-01 00:27:33announcedUpdated publication reference for PubMed record(s): 30915077.

Publication List

  1. Chapman EA, Lyon M, Simpson D, Mason D, Beynon RJ, Moots RJ, Wright HL, Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus. Front Immunol, 10():423(2019) [pubmed]

Keyword List

  1. submitter keyword: Neutrophil extracellular traps, PMA, A23187, rheumatoid arthritis, systemic lupus erythematosus

Contact List

    Dr Helen L Wright
    • contact affiliation: Arthritis Research UK Career Development Fellow Institute of Aging and Chronic Disease University of Liverpool
    • contact email: hlwright@liverpool.ac.uk
    • lab head:
    Deborah Simpson
    • contact affiliation: University of Liverpool
    • contact email: dsimpson@liverpool.ac.uk
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List

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