PXD019968

PXD019968 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated Proteomics Characterization of SARS-CoV-2 Associated Liver Injury
Description	The high incidence of liver injury in patients with COVID-19 and the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver. Here, we have identified significant proteomic changes for the first time in the liver of patients with COVID-19 using a quantitative proteomics approach. We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection. These findings reveal important molecular mechanisms that may play a key role in the pathogenesis of COVID-19 associated liver diseases and provide a scientific basis for medical intervention strategy and drug target selection.
HostingRepository	iProX
AnnounceDate	2020-06-23
AnnouncementXML	Submission_2022-01-26_17:43:52.323.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ruiyuan Cao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-23 01:21:56	ID requested
⏵ 1	2022-01-26 17:43:54	announced

Publication List

Leng L, Cao R, Ma J, Lv L, Li W, Zhu Y, Wu Z, Wang M, Zhou Y, Zhong W, Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther, 6(1):9(2021) [pubmed]

Leng L, Cao R, Ma J, Lv L, Li W, Zhu Y, Wu Z, Wang M, Zhou Y, Zhong W, Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther, 6(1):9(2021) [pubmed]

Keyword List

submitter keyword: COVID-19, SARS-CoV-2, proteomic, liver metabolism, NF-κB, drug target

submitter keyword: COVID-19, SARS-CoV-2, proteomic, liver metabolism, NF-κB, drug target

Contact List

Wu Zhong
contact affiliation	National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology.
contact email	zhongwu@bmi.ac.cn
lab head
Ruiyuan Cao
contact affiliation	National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology.
contact email	21cc@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI