PXD006442 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deciphering of the human interferome and its kinetics of protein induction and repression by mass spectrometry-based quantitative proteome analysis |
Description | Interferons (IFNs) are pleotropic cytokines secreted upon encounter of pathogens and tumors. Applying their antipathogenic, antiproliferative and immune stimulatory capacities, recombinant IFNs are frequently prescribed as drugs to treat different diseases. IFNs act by changing the transcription of cells. Due to characteristics like rapid induction and signaling, IFNs represent prototypic model systems for various aspects of biomedical research. In respect to the signaling and activated promoters, IFNs can be subdivided in two groups. Here, alterations of the cellular proteome of human cells treated with IFN and IFN were elucidated in a time-dependent manner by mass spectrometry-based quantitative proteome analysis. The majority of protein regulations were strongly IFN type- and time-dependent. In addition to the expected upregulation of IFN-induced proteins, an astonishing number of proteins become profoundly repressed especially by IFN. Taken together, our comprehensive analysis deciphers the human interferome and its kinetics of protein induction and repression. |
HostingRepository | PRIDE |
AnnounceDate | 2018-05-25 |
AnnouncementXML | Submission_2018-05-25_02:48:11.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD006442 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Dominik Andre Meger |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-05-03 07:13:37 | ID requested | |
⏵ 1 | 2018-05-25 02:48:12 | announced | |
Publication List
Megger DA, Philipp J, Le-Trilling VTK, Sitek B, Trilling M, Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression. Front Immunol, 8():1139(2017) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Label-free quantification, interferome, interferon alpha, interferon gamma |
Contact List
Dominik Andre Megger |
contact affiliation | 1) Medizinisches Proteom-Center, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany 2) Institute of Virology, University Hospital, University Duisburg-Essen, Hufelandstr. 55, 45120 Essen, Germany |
contact email | dominik.megger@rub.de |
lab head | |
Dominik Andre Meger |
contact affiliation | Medizinisches Proteom-Center (MPC), Ruhr-Universität Bochum, Germany |
contact email | dominik.megger@rub.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD006442 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006442
- Label: PRIDE project
- Name: Deciphering of the human interferome and its kinetics of protein induction and repression by mass spectrometry-based quantitative proteome analysis