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PXD009799-1

PXD009799 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleICAP2 Immunoprecipitation results
DescriptionThe mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex. However, sequence-based searches fail to identify genes encoding stator subunits in apicomplexan parasites like Toxoplasma gondii or the related organisms that cause malaria. Here, we identify 11 previously unknown subunits from the Toxoplasma ATP synthase, which lack homologs outside the phylum. Hidden Markov modeling suggests that two of them—ICAP2 and ICAP18—share distant homology with mammalian stator subunits. Our mass spcetrometry analysis indicates that both proteins form part of the ATP synthase complex.
HostingRepositoryPRIDE
AnnounceDate2018-08-22
AnnouncementXMLSubmission_2018-08-22_04:15:25.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD009799
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDiego Huet
SpeciesList scientific name: Toxoplasma gondii ME49; NCBI TaxID: 508771;
ModificationListOxidation; Carbamidomethyl
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-05-16 06:00:17ID requested
12018-08-22 04:15:26announced
22024-10-22 04:45:16announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: Toxoplasma, ATP synthase, mitochondria
Contact List
Sebastian Lourido
contact affiliationWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts USA
contact emaillourido@wi.mit.edu
lab head
Diego Huet
contact affiliationWhitehead Institute
contact emaildhuet@wi.mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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