<<< Full experiment listing

PXD019942

PXD019942 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleParallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translation
DescriptionTARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that coordinates eukaryotic metabolism with nutrient availability. In mammals, TOR specifically promotes translation of ribosomal protein mRNAs when amino acids are available to support protein synthesis. The mechanisms controlling translation downstream from TOR remain contested, however, and are largely unexplored in plants. Here, we took parallel global profiling approaches to define the in planta TOR-regulated proteome, and phosphoproteome. We found that TOR regulates ribosome biogenesis in plants at multiple levels. To investigate this further, we focused on a putative TOR substrate identified in our phosphoproteome: LARP1, a eukaryotic RNA-binding protein that is proposed to mediate TOR translational control of 5′TOP mRNAs in humans.
HostingRepositoryPRIDE
AnnounceDate2021-01-05
AnnouncementXMLSubmission_2021-01-05_00:29:07.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD019942
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMaria Regina Scarpin
SpeciesList scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-22 03:09:54ID requested
12021-01-05 00:29:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Arabidopsis thaliana, seedlings, LC-MSMS
Contact List
Jacob O. Brunkard
contact affiliationDepartment of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA Plant Gene Expression Center, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA
contact emailbrunkard@berkeley.edu
lab head
Maria Regina Scarpin
contact affiliationPostdoctoral researcher
contact emailreginascarpin@berkeley.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD019942
PRIDE project URI
Repository Record List
[ + ]