PXD019942 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translation |
Description | TARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that coordinates eukaryotic metabolism with nutrient availability. In mammals, TOR specifically promotes translation of ribosomal protein mRNAs when amino acids are available to support protein synthesis. The mechanisms controlling translation downstream from TOR remain contested, however, and are largely unexplored in plants. Here, we took parallel global profiling approaches to define the in planta TOR-regulated proteome, and phosphoproteome. We found that TOR regulates ribosome biogenesis in plants at multiple levels. To investigate this further, we focused on a putative TOR substrate identified in our phosphoproteome: LARP1, a eukaryotic RNA-binding protein that is proposed to mediate TOR translational control of 5′TOP mRNAs in humans. |
HostingRepository | PRIDE |
AnnounceDate | 2021-01-05 |
AnnouncementXML | Submission_2021-01-05_00:29:07.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD019942 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Maria Regina Scarpin |
SpeciesList | scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-22 03:09:54 | ID requested | |
⏵ 1 | 2021-01-05 00:29:07 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Arabidopsis thaliana, seedlings, LC-MSMS |
Contact List
Jacob O. Brunkard |
contact affiliation | Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA Plant Gene Expression Center, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA |
contact email | brunkard@berkeley.edu |
lab head | |
Maria Regina Scarpin |
contact affiliation | Postdoctoral researcher |
contact email | reginascarpin@berkeley.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019942
- Label: PRIDE project
- Name: Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translation