PXD020252-1
PXD020252 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative proteomic characterization of human lung adenocarcinoma |
| Description | Genomic studies of lung adenocarcinoma (LUAD) have advanced understanding of the disease’s biology and accelerated targeted therapy. However, proteomic characteristics of LUAD remain poorly understood. We carried out comprehensive proteomic analysis of 103 cases of LUAD in Chinese patients. Integrative analysis of proteome, phosphoproteome, transcriptome, and whole-exome sequencing data revealed cancer associated characteristics, such as tumor-associated protein variants, distinct proteomic features, and clinical outcomes in patients of early stage or with EGFR and TP53 mutations. Proteome-based stratification of LUAD revealed three subtypes (S-I, S-II, S-III) related to different clinical and molecular features. Further, we nominated potential drug targets and validated the plasma protein level of HSP 90β as a potential prognostic biomarker for LUAD in an independent cohort. Our integrative proteomic analysis gives a more comprehensive understanding on the molecular landscape of LUAD and offers the opportunity for more precise diagnosis and treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2020-07-08 |
| AnnouncementXML | Submission_2020-07-09_17:37:07.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Linhui Zhai |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-07-07 21:35:40 | ID requested | |
| ⏵ 1 | 2020-07-09 17:37:08 | announced | |
| 2 | 2020-08-04 00:33:38 | announced | 2020-08-04: Update publication information |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LUAD, proteomics, phosphoproteomics |
Contact List
| Minjia Tan | |
|---|---|
| contact affiliation | Shanghai Institute of Materia Medica |
| contact email | mjtan@simm.ac.cn |
| lab head | |
| Linhui Zhai | |
| contact affiliation | Shanghai Institute of Materia Medica |
| contact email | zhailinhui@simm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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