PXD029382

PXD029382 is an original dataset announced via ProteomeXchange.

Title	Graphene Oxide Attenuates Toxicity of Amyloid-β Aggregates in Yeast by Promoting Disassembly and Boosting Cellular Stress Response
Description	Alzheimer’s disease (AD) is the most common form of neurodegenerations, with oligomerization and aggregation of amyloid-β peptides (Aβ) being one of its histopathological hallmarks. Recently, graphene oxide (GO) nanoflakes have attracted significant attention in biomedical fields by suppression of protein aggregation in vitro. However, the impact of GO on aggregated proteins in vivo is poorly understood. In earlier work, we developed a humanized AD model in yeast Saccharomyces cerevisiae by constitutively expressing Aβ42 peptides to mimic the chronic cytotoxicity during AD progression. Here we apply this in vivo model system to investigate the impact of GO on Aβ42 aggregates and cytotoxicity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:04:09.432.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vaishnavi Ravikumar
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-27 08:14:07	ID requested
1	2023-09-28 07:49:34	announced
2	2023-11-14 08:52:41	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:04:09	announced	2024-10-22: Updated project metadata.

10.1002/ADFM.202304053;

submitter keyword: Alzheimer’s disease, graphene oxide, amyloid-β,Saccharomyces cerevisiae

Ivan Mijakovic
contact affiliation	Professor Head of Divison of Systems and Synthetic Biology Department of Biology and Biological Engineering Chalmers University of Technology Kemivägen 10, SE-412 96 Göteborg, SWEDEN
contact email	ivan.mijakovic@chalmers.se
lab head
Vaishnavi Ravikumar
contact affiliation	Copenhagen University Hospital
contact email	vaishnavi.ravikumar@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD029382

PRIDE project URI

• PRIDE
  1. PXD029382
     1. Label: PRIDE project
     2. Name: Graphene Oxide Attenuates Toxicity of Amyloid-β Aggregates in Yeast by Promoting Disassembly and Boosting Cellular Stress Response