PXD037861 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Physiological profile of the coronary artery and internal thoracic artery endothelial cells as a basis for the structural and functional congrunce of the arterio-arterial continuum |
| Description | Currently, it is well established that human endothelial cells (ECs) are characterised by a significant heterogeneity between distinct blood vessels, e.g., arteries, veins, capillaries, and lymphatic vessels. Further, even ECs belonging to the same lineage but grown under different flow patterns (e.g., laminar and oscillatory or turbulent flow) ostensibly have distinct molecular profiles defining their physiological behaviour. Human coronary artery endothelial cells (HCAEC) and human internal thoracic artery endothelial cells (HITAEC) represent two cell lines inhabiting atheroprone and atheroresistant blood vessels (coronary artery and internal thoracic artery, respectively). Resistance of the internal mammary artery to atherosclerosis has been largely attributed to the protective phenotype of HITAEC which reportedly produce higher amounts of vasodilators including nitric oxide (NO) through the respective signaling pathways. However, this hypothesis has not been adequately addressed hitherto as proteomic profiling of HCAEC and HITAEC in a head-to-head comparison setting has not been performed. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_07:49:27.807.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037861 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Arseniy Lobov |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-10-31 09:22:33 | ID requested | |
| 1 | 2023-10-17 11:21:06 | announced | |
| ⏵ 2 | 2023-11-14 07:49:28 | announced | 2023-11-14: Updated project metadata. |
| 3 | 2024-10-22 06:06:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: endothelium, PASEF, Tims ToF Pro |
Contact List
| Anton G. Kutikhin |
|---|
| contact affiliation | Head of the Laboratory for Vascular Biology, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases Kemerovo, Russian Federation |
| contact email | antonkutikhin@gmail.com |
| lab head | |
| Arseniy Lobov |
|---|
| contact affiliation | Emmanuel Levy Lab, Dept. of Chemical and Structural Biology, Weizmann Institute of Science |
| contact email | arseniylobov@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037861
- Label: PRIDE project
- Name: Physiological profile of the coronary artery and internal thoracic artery endothelial cells as a basis for the structural and functional congrunce of the arterio-arterial continuum
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