PXD047246-1

PXD047246 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of HepG2 WT and mitochondrial apolipoprotein MIC26 knockout cells under normo- and hyperglycemic conditions
Description	Increased amounts of the mitochondrial apolipoprotein O /MIC26 were found in diabetic patients along with lipid accumulation in murine liver upon MIC26 expression. MIC26 is a MICOS complex constituent present in the mitochondrial inner membrane. Here, we employed a proteomics analysis approach in WT and MIC26 knockout HepG2 cellular models in normoglycemic and hyperglycemic conditions.
HostingRepository	PRIDE
AnnounceDate	2024-09-13
AnnouncementXML	Submission_2024-09-13_06:34:50.090.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anja Stefanski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-26 13:18:06	ID requested
⏵ 1	2024-09-13 06:34:50	announced
2	2024-10-22 06:58:12	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Apolipoproteins, MIC26,Mitochondria, MICOS complex and Fatty acid metabolism

Kai Stühler
contact affiliation	Institute of Molecular Medicine, Protein Research, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
contact email	kai.stuehler@hhu.de
lab head
Anja Stefanski
contact affiliation	Molecular Proteomics Laboratory
contact email	anja.stefanski@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD047246

PRIDE project URI

• PRIDE
  1. PXD047246
     1. Label: PRIDE project
     2. Name: Proteome analysis of HepG2 WT and mitochondrial apolipoprotein MIC26 knockout cells under normo- and hyperglycemic conditions